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- W2364889464 abstract "Objective To explore the effect of α-Asarone in different concentration on spatial learning and memory capacity of the epilepsy rats.Methods Fifty males Sprague-Dawley rats were divided into two groups randomly,as normal control group(n=10) and epileptic model group(n=40).The epileptic model group were divided further into four groups randomly.Each group of 10 only,as Kainic acid(KA)group,α-Asarone low concentration group,α-Asarone moderate concentration group and α-Asarone high concentration group.The α-Asarone group rats were injected intraperitoneally with α-Asarone once a day for ten days.The changes of movement were observed,including plate test,over hanging test and Morris water maze test,and the effects of α-Asarone at 24h,10d,and 30d were evaluated.Results The ability of rats in KA group on writhing body,suspending body,and as spatial learning ability and memory were obviously decreased compared to normal control group(P0.05).The low concentration group was secondary to the KA group.But there was no obvious difference among the moderate concentration group and the high concentration group compared to the normal control group(P0.05).Conclusion The epilepsy rats kindled by KA suffer the damage of spatial learning ability and memory function.It will improve the epilepsy rat′s spatial learning ability and memory function by using α-Asarone." @default.
- W2364889464 created "2016-06-24" @default.
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- W2364889464 date "2012-01-01" @default.
- W2364889464 modified "2023-09-24" @default.
- W2364889464 title "Effects of α-Asarone on spatial learning and memory capacity of epilepsy rats kindled by Kainic acid" @default.
- W2364889464 hasPublicationYear "2012" @default.
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