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- W2364892108 abstract "The effects of(1R,2R)-SIPI5358 and SIPI5358 on the delayed rectifier potassium current(IK) in undifferentiated PC12 cells were recorded with whole-cell patch clamp technique.The results showed that the two compounds had a concentration-and voltage-dependent inhibition on IK.The IC50 values of(1R,2R)-SIPI5358 and SIPI5358 were(0.64±0.17) and(12.05±3.31)μmol/L,respectively.The(1R,2R)-SIPI5358 at the concentration of 1 μmol/L shifted the IK steady-state activation and inactivation curves in the hyperpolarizing direction by 4 and 20 mV.The SIPI5358 at the concentration of 20 μmol/L shifted the IK steady-state activation curve in the depolarizing direction by 7 mV and shifted the inactivation curve in the hyperpolarizing direction by 21 mV.The effects of(1R,2R)-SIPI5358 and SIPI5358 on IK might be related to their neurotoxicity." @default.
- W2364892108 created "2016-06-24" @default.
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- W2364892108 date "2012-01-01" @default.
- W2364892108 modified "2023-09-24" @default.
- W2364892108 title "Inhibition of(1R,2R)-SIPI5358 and SIPI5358 on Delayed Rectifier Potassium Current in Undifferentiated PC12 Cells" @default.
- W2364892108 hasPublicationYear "2012" @default.
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