FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2364892243> ?p ?o ?g. }

• W2364892243 endingPage "252" @default.
• W2364892243 startingPage "251" @default.
• W2364892243 abstract "Chronic fatigue syndrome (CFS) is an illness characterized by unexplained fatigue lasting at least 6 months that is not relieved by rest, which affects different body systems and results in cognitive problems, muscle pains, sleep problems, and so on. Physical or mental activity could worsen this illness. CFS is a widespread problem, and estimate for the prevalence of CFS varies widely from 0.007% to 2.8% 1. At present, diagnosis of CFS usually depends on subjective self-reported feeling and can be made only when other etiologies of fatigue have been excluded. For example, the commonly used criteria for diagnosing CFS include headache, pain in multiple joints or muscles, impaired memory, concentration, and sleep. However, these conditions are also frequently associated with other psychosocial factors, such as sleep disorder, depression, and anxiety 2, 3. Therefore, discovering associated characteristic biomarkers are essential for improving the diagnosis and treatment of CFS. Orosomucoid (ORM) is an acute phage protein which has many biological activities including modulating immunity, carrying drugs, maintaining the barrier function of capillary, mediating the sphingolipid metabolism, and also acting as an disease marker 4. In our previous study, we found that ORM was significantly upregulated in serum of various forms of fatigued rodents, especially dominantly in sleep-deprivation rats which have been used in the study of CFS 5, 6. To explore whether ORM could be utilized as a biomarker for CFS, we examined the serum level of ORM in 46 patients diagnosed with CFS according to CDC diagnosis criteria 7 and a group of 38 healthy volunteers. A significantly elevated level of ORM was found in sera from CFS patients (2.78 mg/mL) compared with that from healthy volunteers (0.44 mg/mL) (Figure 1A). The levels of ORM in sera from the volunteers are all lower than 1 mg/mL, whereas sera from 45 of the 46 CFS individuals contain ORM level higher than 1 mg/mL (Figure 1B). Glucocorticoids are known as a major regulator of ORM expression. However, the serum cortisol level in these CFS patients was moderately decreased (Figure 2),which is in accordance previous studies which reported mild hypocortisolism in CFS patients indicating clinically relevant hypothalamic–pituitary–adrenal (HPA) axis dysfunction 8. These findings indicated that the ORM increase is not a direct result of stress response. Fatigue is a commonly experienced, but nonspecific and highly subjective symptom. Detecting and evaluating fatigue is a common task both in various society activities and in clinical practice. At present, there are still no specific factors that have been consistently associated with CFS, and there are no official or semi-official recommendations for the treatment of CFS 9. We found in this study that ORM is significantly elevated in sera from individuals with CFS. The ORM protein contains genetic polymorphisms. In human, there are two isoforms of ORM 4. Interestingly, it has been shown through proteomics analysis that increased ORM2 is a characteristic change in cerebrospinal fluid from patients diagnosed with CFS 10. These results suggest that it is worth to further explore whether ORM family protein could be used as a biomarker for CFS in the future. This work was supported by grants from the National Natural Science Foundation of China (81273606 and 81473259 to XL, 81230083 to DFS), and National Science and Technology Major Project (2014ZX09J14103-08C to XL). The authors declare no competing financial interests. The authors declare no conflict of interest." @default.
• W2364892243 created "2016-06-24" @default.
• W2364892243 creator A5024871143 @default.
• W2364892243 creator A5034266315 @default.
• W2364892243 creator A5053411040 @default.
• W2364892243 date "2016-02-02" @default.
• W2364892243 modified "2023-10-14" @default.
• W2364892243 title "Orosomucoid (ORM) as a Potential Biomarker for the Diagnosis of Chronic Fatigue Syndrome (CFS)" @default.
• W2364892243 cites W1547771930 @default.
• W2364892243 cites W1836958062 @default.
• W2364892243 cites W1991081852 @default.
• W2364892243 cites W2051892927 @default.
• W2364892243 cites W2058705093 @default.
• W2364892243 cites W2098287790 @default.
• W2364892243 cites W2110255764 @default.
• W2364892243 cites W2111704329 @default.
• W2364892243 cites W2225014658 @default.
• W2364892243 cites W3143129303 @default.
• W2364892243 doi "https://doi.org/10.1111/cns.12522" @default.
• W2364892243 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6492840" @default.
• W2364892243 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26833758" @default.
• W2364892243 hasPublicationYear "2016" @default.
• W2364892243 type Work @default.
• W2364892243 sameAs 2364892243 @default.
• W2364892243 citedByCount "8" @default.
• W2364892243 countsByYear W23648922432016 @default.
• W2364892243 countsByYear W23648922432018 @default.
• W2364892243 countsByYear W23648922432020 @default.
• W2364892243 countsByYear W23648922432021 @default.
• W2364892243 countsByYear W23648922432022 @default.
• W2364892243 countsByYear W23648922432023 @default.
• W2364892243 crossrefType "journal-article" @default.
• W2364892243 hasAuthorship W2364892243A5024871143 @default.
• W2364892243 hasAuthorship W2364892243A5034266315 @default.
• W2364892243 hasAuthorship W2364892243A5053411040 @default.
• W2364892243 hasBestOaLocation W23648922431 @default.
• W2364892243 hasConcept C118552586 @default.
• W2364892243 hasConcept C121446783 @default.
• W2364892243 hasConcept C126322002 @default.
• W2364892243 hasConcept C137627325 @default.
• W2364892243 hasConcept C139719470 @default.
• W2364892243 hasConcept C162324750 @default.
• W2364892243 hasConcept C185592680 @default.
• W2364892243 hasConcept C2776867660 @default.
• W2364892243 hasConcept C2778329153 @default.
• W2364892243 hasConcept C2779134260 @default.
• W2364892243 hasConcept C2779566273 @default.
• W2364892243 hasConcept C2781197716 @default.
• W2364892243 hasConcept C3020395016 @default.
• W2364892243 hasConcept C55493867 @default.
• W2364892243 hasConcept C558461103 @default.
• W2364892243 hasConcept C71924100 @default.
• W2364892243 hasConceptScore W2364892243C118552586 @default.
• W2364892243 hasConceptScore W2364892243C121446783 @default.
• W2364892243 hasConceptScore W2364892243C126322002 @default.
• W2364892243 hasConceptScore W2364892243C137627325 @default.
• W2364892243 hasConceptScore W2364892243C139719470 @default.
• W2364892243 hasConceptScore W2364892243C162324750 @default.
• W2364892243 hasConceptScore W2364892243C185592680 @default.
• W2364892243 hasConceptScore W2364892243C2776867660 @default.
• W2364892243 hasConceptScore W2364892243C2778329153 @default.
• W2364892243 hasConceptScore W2364892243C2779134260 @default.
• W2364892243 hasConceptScore W2364892243C2779566273 @default.
• W2364892243 hasConceptScore W2364892243C2781197716 @default.
• W2364892243 hasConceptScore W2364892243C3020395016 @default.
• W2364892243 hasConceptScore W2364892243C55493867 @default.
• W2364892243 hasConceptScore W2364892243C558461103 @default.
• W2364892243 hasConceptScore W2364892243C71924100 @default.
• W2364892243 hasFunder F4320321001 @default.
• W2364892243 hasIssue "3" @default.
• W2364892243 hasLocation W23648922431 @default.
• W2364892243 hasLocation W23648922432 @default.
• W2364892243 hasLocation W23648922433 @default.
• W2364892243 hasLocation W23648922434 @default.
• W2364892243 hasOpenAccess W2364892243 @default.
• W2364892243 hasPrimaryLocation W23648922431 @default.
• W2364892243 hasRelatedWork W1972835821 @default.
• W2364892243 hasRelatedWork W1976890251 @default.
• W2364892243 hasRelatedWork W2020988236 @default.
• W2364892243 hasRelatedWork W2214045728 @default.
• W2364892243 hasRelatedWork W2252519151 @default.
• W2364892243 hasRelatedWork W2349148920 @default.
• W2364892243 hasRelatedWork W2377610433 @default.
• W2364892243 hasRelatedWork W2381160011 @default.
• W2364892243 hasRelatedWork W4295350606 @default.
• W2364892243 hasRelatedWork W158384855 @default.
• W2364892243 hasVolume "22" @default.
• W2364892243 isParatext "false" @default.
• W2364892243 isRetracted "false" @default.
• W2364892243 magId "2364892243" @default.
• W2364892243 workType "article" @default.