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- W2364894125 abstract "Loss of cell polarity is commonly observed in most human cancers derived from epithelial tissues.However,the contribution of cell polarity disruption to tumor progression has been unknown.Recently,the molecular mechanisms that control cellular polarization were gradually uncovered.Meanwhile,it was found that this molecular machinery is intimately involved in tumorigenesis.During the formation of apical-basal cell polarity,Scrib complex and Par complex antagonize reciprocally to determine the apical and basolateral membrane domains.Once the fine balance between their activities is broken due to the inhibition of Scrib complex or the activation of Par complex,cancer or other developmental disease will appear.Here we will discuss how the interactions between Scrib complex and Par complex are implicated in the establishment of apical-basal cell polarity and their contributions to tumorigenesis." @default.
- W2364894125 created "2016-06-24" @default.
- W2364894125 creator A5042377014 @default.
- W2364894125 date "2010-01-01" @default.
- W2364894125 modified "2023-09-28" @default.
- W2364894125 title "Scrib Complex and Par Complex:From Apical-basal Polarity to Tumorigenesis" @default.
- W2364894125 hasPublicationYear "2010" @default.
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