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- W2364895725 abstract "Objective Colorectal cancer is a common gastroenteric malignancy,which has an increasing incidence in the recent years and therefore calls for the exploration of new treatment.Our study is to investigate the effect of recombinant immunotoxin(IT) anti-c-Met/PE38KDEL on the proliferation and apoptosis of human colorectal cancer cell lines.Methods Human colorectal cancer cell lines Colo205 and SW480 were treated with different concentrations of IT.The inhibition of the cell proliferation was determined by Cell Counting Kit-8 assay(CCK-8) at 24 and 48 hours,that of protein synthesis evaluated by -leucine incorporation assay at 5 and 24 hours,and the changes in the activity of caspase-3 and caspase-8 detected by designated caspase colorimetric protease assay.Results IT treatment significantly decreased the growth and protein synthesis of the colorectal cancer cells in a dose-and time-dependent manner,with more obvious effect at 10 and 100 ng/ml(P0.01),and remarkably increased the activity of caspase-3 and caspase-8 at 100 ng/ml.Conclusion Recombinant IT anti-c-Met/PE38KDEL can inhibit the proliferation and induce the apoptosis of human colorectal cancer cell lines,which has offered some evidence for targeted therapies for colorectal cancer." @default.
- W2364895725 created "2016-06-24" @default.
- W2364895725 creator A5084583835 @default.
- W2364895725 date "2011-01-01" @default.
- W2364895725 modified "2023-09-23" @default.
- W2364895725 title "Effects of recombinant immunotoxin anti-c-Met/PE38KDEL on the proliferation and apoptosis of human colorectal cancer cell lines" @default.
- W2364895725 hasPublicationYear "2011" @default.
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