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- W2364896185 abstract "Objective To study the effect of inactivation htrA or clpP on the the acid tolerance of Streptococcus mutans.Methods Strains were grown to mid-logarithmic growth phase and devided into experimental group and control group.Experimental group was resuspended in TPY with pH 5.5 for 5 h as adapted strains.The control group was treated in TPY at pH 7.0 for 5 h as unadapted strains.Then the two groups were sustained in a lethal TPY with pH 3.0 for 3 h,the survival rate of strain was calculated every hour.All the data were statistically analyzed.Results The survival rates of the three unadapted strains was not statistically significant within 3 h(P0.05).The viabilities of the survival rate of htrA adapted mutant strain and clpP adapted mutant strain was significantly lower than that of adapted standard stain(P0.05).Compared with the survival rate of htrA adapted mutant strain,there were no obvious differences in the survival rate of the clpP adapted mutant strain(P0.05).The survival rates of adapted standard strain and htrA adapted mutant strain were higher than that of the same unadapted strains(P0.05).The effect of TPY at pH 5.5 on strain was higher than that of the two genes knockouted(P0.05).Conclusions Compared with Streptococcus mutans standard strain,the abilities of the acid tolerance of htrA mutant strain and clpP mutant strain declined to various degrees." @default.
- W2364896185 created "2016-06-24" @default.
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- W2364896185 date "2012-01-01" @default.
- W2364896185 modified "2023-09-24" @default.
- W2364896185 title "Effect of of htrA and clpP mutation on the ability of the acid tolerance of Streptococcus mutans" @default.
- W2364896185 hasPublicationYear "2012" @default.
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