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- W2364896675 abstract "Objective To observe the effects of taurolidine on radiosensitivity of B16-F10 cells of murine melanoma via the enhancement of Bax and Bad proteins and induction of Bcl-2 protein.Methods The apoptosis of B16-F10 cells was assessed after treated with 0,10,25,50,100 and 150 μmol·L-1 taurolidine,clone survival assay was used to detect the radiosensitivity of B16-F10 cells,and protein expressions were determined by Western blotting.Results The apoptosis of 5% cells was induced in a dose-and time-dependent manner after B16-F10 cells were treated with 50 μmol·L-1 taurolidine.The survival rate decreased after treated with taurolidine in combination with 2 Gy X-irradiation with the increase of taurolidine concentration and doses of irradiation(P0.05),and the ratio of radiosensitivity (SER D0 and SER Dq) also increased with the increase of its concentration,there was significant difference between 50 μmol·L-1 taurolidine group and 10 μmol·L-1 taurolidine group(P0.05); meantime,the level of proapototic protein Bax and Bad increased and the level of antiapoptotic protein Bcl-2 reduced.Conclusion Taurolidine in combination with irradiation can enhance the radiaosensitivity by the mediation of Bcl-2 family protein." @default.
- W2364896675 created "2016-06-24" @default.
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- W2364896675 date "2008-01-01" @default.
- W2364896675 modified "2023-09-23" @default.
- W2364896675 title "Effects of taurolidine on radiosensitivity of murine melanoma cells and its mechanism" @default.
- W2364896675 hasPublicationYear "2008" @default.
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