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- W2364897906 abstract "Objective To investigate the expressions of Insulin-like growth factor 1 and Insulin like growth factor binding protein 3 in serum and bronchoalveolar lavagae fluids(BALF) of patients with non-small cell lung cancer,and discuss the clinical value in dignosis and prognosis of lung cancer.Methods BALF were collected by bronchoscopy in 80 cases of non-small cell lung cancer and 14 cases of health.The expression of IGF-1、IGFBP-3 in serum and BALF were analysed by immunoradioassay.Results The expression of IGF-1 and IGF-1/IGFBP-3 in serum and BALF of lung cancer group were significantly higher than those of health group(P0.01);but the IGFBP-3 levels were significantly lower than that of health group(P0.05).IGF-1 and IGF-1/IGFBP-3 in serum and BALF were higher in patients with lymphoid node metastasis or metastasis or TNM Ⅲ～Ⅳ than those without Metastasis or TNMⅠ～Ⅱ(P0.05),and IGFBP-3 levels were significantly lower in these patients than those without metastasis or TNMⅠ～Ⅱ(P0.05).In lung cancer group,the levels of the IGF-1 and IGF-1/IGFBP-3 in serum had a significantly positive correlation with those in BALF respectly(P0.01),the levels of the IGF-1 in serum and BALF had a significantly negative correlation with IGFBP-3 respectly(P0.05).Conclusions The IGF-1,IGFBP-3 in serum and BALF play important roles in the developing of non-small cell lung cancer,examination of them may have clinical value in dignosis and prognosis of lung cancer." @default.
- W2364897906 created "2016-06-24" @default.
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- W2364897906 date "2007-01-01" @default.
- W2364897906 modified "2023-09-24" @default.
- W2364897906 title "Clinical significance of insulin-like growth factor 1 and insulin like growth factor binding protein 3 in serum and bronchoalveolar lavagae fluids of patients with lung cancer" @default.
- W2364897906 hasPublicationYear "2007" @default.
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