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- W2364903987 abstract "[Purpose] To investigate the natural history of low-grade cervical intraepithelial neoplasia (CIN 1), and to explore the validity of p16 hypermethylation for predicting the prognosis of CIN 1. [Methods] The women with CIN 1 or normal cervix biopsically proved during the cervical cancer screening program conduct- ed at Yangcheng County, Shanxi Province in 2002 were enrolled in this study. p16 hypermethylation was de- tected in 139 cases with CIN1 and 120 cases with normal cervix by the methylation-specific PCR-DHPLC on tissue blocks. The CIN cases were followed up for 6 years, and p16 hypermethylation as a marker to predict CIN risk was evaluated. [Results] After the 6-year follow-up, the proportion of regression, persistence and progression of CIN 1 was 70.3%, 13.2% and 16.5%, respectively. For the baseline screening, the p16 hyper- mathylation of CIN 1 (24.2%) was higher than that of women with normal cervix(17.6%), but the difference between them was not significant (χ2=1.60,P=0.21); Although the hypermathylation in HPV positive women (23.5%) was higher than that in HPV negative women (15.6%), there was no significant difference between them (χ2=2.01,P=0.17). The persistence or progression of CIN 1 among the population with or without hyper- mathylaion was 20.0% and 34.9%, respectively. No obvious correlation between CIN 1 prognosis and p16 hypermethylation was observed (RR=0.57, 0.26～1.24). [Conclusion] After 6 years follow up, about two thirds of CIN 1 regresses, only one third of them persists or progresses. The relationship between p16 hypermethyla- tion and CIN 1 has not been confirmed, so p16 hypermethylation can not be used as a biomarker to predict the prognosis of CIN 1." @default.
- W2364903987 created "2016-06-24" @default.
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- W2364903987 date "2009-01-01" @default.
- W2364903987 modified "2023-09-28" @default.
- W2364903987 title "Natural History of Low-grade Cervical Intraepithelial Neoplasia and Its Relationship with p16 Hypermethylation" @default.
- W2364903987 hasPublicationYear "2009" @default.
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