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- W2364916918 abstract "Objective:To study the expression of 5-lipoxygenase in rat hepatocellular carcinoma(HCC) and to investigate whether its specific inhibitor Zileuton can prevent hepatocarcinogenesis.Methods: Male Wistar rats were randomly divided into three groups: normal control group(n=5),model group(n=8) and Zileuton group(n=8).HE staining was used for pathological examination of rat liver samples.The expression of 5-lipoxygenase protein,M2-PK and CK19 were detected by immunochemical staining,5-lipoxygenase mRNA was detected by reverse transcriptase-polymerase chain reaction(RT-PCR).Terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick end-labeling(TUNEL) assay was used to detect apoptosis in the liver.Results: DEN successfully induced rat HCC model.In model group,5-lipoxygenase protein was middle or highly expressed,which is significant higher than the control group(P0.01).However,Zileuton group was significant lower than model group(P0.05).M2-PK and CK19 were negative expressed in control group and M2-PK was medium expressed in model group(P0.01),while in Zileuton group M2-PK was poorly expressed.CK19 was strongly detected in model group,while in Zileuton group was slightly expressed(P0.05).5-lipoxygenase mRNA in control group was expressed significant lower than model group(P0.05),Zileuton group was between them(P0.05).TUNEL assay showed that almost no apoptosis occurred in control group and the model group rats liver expressed minority hepatoma carcinoma cell masculine(30%-50%).However in Zileuton group rats liver found multiplicity hepatoma carcinoma cell masculine expressed(70%-80%)statistically higher compared with the model group(P0.05).Conclusion: DEN induced rat HCC have 5-lipoxygenase expressed.Inhibition of 5-lipoxygenase by Zileuton exerts inhibitory effect on the development of HCC in rats induced 5-lipoxygenase.The mechanism may be associated with induction of apoptosis." @default.
- W2364916918 created "2016-06-24" @default.
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- W2364916918 date "2011-01-01" @default.
- W2364916918 modified "2023-09-27" @default.
- W2364916918 title "Zileuton,a 5-lipoxygenase specific inhibitor prevents hepatocarcinogenesis induced by diethylnitrosamine in rats and its mechanism" @default.
- W2364916918 hasPublicationYear "2011" @default.
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