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- W2364936719 abstract "Objective To evaluate the effect of Alanyl-glutamine on serum HSP70 concentration and Murray lung injury score(MLIS) and the duration of mechanical ventilation in ALI/ARDS patients.Methods One hundred and ten patients admitted to emergency intensive care unit were randomly divided into control group and Alanyl-glutamine group.50 patients in the control group were given routine treatment including primary disease treatment,mechanical ventilation,fluid management and nutrition support,and 60 patients in the Alanyl-glutamine group were given Alanyl-glutamine at a dose of 0.4 g·kg-1·d-1 for 7 days besides the routine treatment.Serum HSP70 concentrations were measured before and after the 7th treating day.MLIS and the hours of mechanical ventilation were observed at the same time.Results After treatment,HSP70 concentrations in Alanyl-glutamine group were significantly higher than those in control group(P0.01),and MLIS were significantly decreased in Alanyl-glutamine group(P0.01).The hours of mechanical ventilation in Alanyl-glutamine group(162.20±96.33) h were significantly shortened than those of the control group(235.00±107.90)h(P0.05).But there was no singnificant difference of mortality at day 28 between the two groups.Conclusion Alanyl-glutamine can significantly increase serum HSP70 concentrations and decrease MLIS as well as shorten the duration of mechanical ventilation in ALI/ARDS patients." @default.
- W2364936719 created "2016-06-24" @default.
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- W2364936719 date "2011-01-01" @default.
- W2364936719 modified "2023-09-23" @default.
- W2364936719 title "The Effect of Alanyl-Glutamine on HSP70 and MLIS and the Duration of Mechanical Ventilation in ALI/ARDS Patients" @default.
- W2364936719 hasPublicationYear "2011" @default.
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