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- W2364941134 abstract "AIM: To study the protective effect of human high-density lipoproteins (hHDL) on hepatocytes. METHODS: The human plasma lipoproteins were isolated and purified by ultracentrifugation. The mouse model with acute hepatic failure was established by endotoxin and galactosamine. The survival rates of the mice with hepatic failure were compared between the hHDL- treated group and the control group. The histological alterations of the important organs were also compared between the two groups. The mRNA expressions of TNFα and IL-6 were detected by RT-PCR. RESULTS: The survival rate of the mice in the hHDL-treated group was significantly higher than that in the control group (85% vs 15%), which suggested a significant protective effect of hHDL against acute hepatic failure. Extensive degeneration and necrosis of the hepatocytes were found in control group, however slight degeneration and necrosis of the hepatocytes occurred in the hHDL- treated group. The mRNA expression levels of TNFα and IL-6 in the liver of the hHDL- treated group were significantly lower than those in the control group. CONCLUSION: HDL counteracts endotoxin and is of obviously preventive against hepatic failure probably by decreasing the expressions of TNFα and IL-6." @default.
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- W2364941134 date "2007-01-01" @default.
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- W2364941134 title "Protective effect of human high-density lipoproteins against acute hepatic failure induced by endotoxin in mice" @default.
- W2364941134 hasPublicationYear "2007" @default.
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