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- W2364941381 abstract "[Objective]To study the expression of PDX-1 protein and mRNA in breast cancers with different clinic pathological characteristics or molecular subtypes,to analyze its correlation and provide its effect in the incidence,development and prognosis of breast cancer.[Methods]Immunohistochemistry and Real-Time RT-PCR were performed respectively to determine PDX-1 protein and mRNA in different breast samples,including breast cancer,benign lesions,neighboring non-cancerous tissues or different groups with molecular subtypes.[Results]The expression of PDX-1 protein in the breast cancer group was higher than that in breast benign lesions group and neighboring non-cancerous tissue group(P﹤0.01).The expression of PDX-1 protein or mRNA had a correlation with lymph node metastasis,differentiation or clinical stage(P﹤0.05).There was no correlation of PDX-1 protein or mRNA expression with age,histological types,tumor size(P﹥0.05).The expressions of PDX-1 protein and PDX-1 mRNA in luminal subtype A and luminal subtype B were higher than those in Her-2 over expression subtype,basal-cell like subtype and unclassified subtype(P﹤0.05).Real-Time RT-PCR data revealed a PDX-1 mRNA expression pattern was identical to that of protein expression.[Conclusion]It is possible that PDX-1 would be as a biomarker for breast cancers or a new candidate gene in molecular subtypes of breast cancer." @default.
- W2364941381 created "2016-06-24" @default.
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- W2364941381 date "2011-01-01" @default.
- W2364941381 modified "2023-09-24" @default.
- W2364941381 title "THE RESEARCH OF THE RELATION BETWEEN PDX-1 AND BREAST CANCER" @default.
- W2364941381 hasPublicationYear "2011" @default.
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