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- W2364943721 abstract "Objective: To explore whether TNF-related apoptosis inducing ligand(TRAIL)and death receptor-5(DR5) take part in the occurrence and development of atherosclerosis(AS).Methods: Twenty rabbits were randomly distributed into two groups: the control group and the atherosclerotic group.The experimental atherosclerotic models were made by endothelial injury on the ventro-aorta with a balloon and hyperlipid feeding lasting 12 weeks.The levels of sTRAIL and sDR5 in the serum were determined by enzyme linked immunoabsorbent assay(ELISA).The proteinum expression of TRAIL and DR5 in the ventro-aortas was detected by immunohistochemical technique.Results: In the course of research,2 rabbits died.The survival rate was 90%.Till the end of the research,the serum sDR5 in the AS group was more significantly elevated than that in control group(P0.05),while the serum sTRAIL in two groups had no significant differences(P0.05).The expressions of TRAIL and DR5 in the ventro-aortas in the AS group were significantly elevated than those in the control group(P0.05).Conclusion: This study suggests that TRAIL and DR5 could promote the occurrence and development of AS.TRAIL and DR5 may be important factors for AS." @default.
- W2364943721 created "2016-06-24" @default.
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- W2364943721 date "2007-01-01" @default.
- W2364943721 modified "2023-09-24" @default.
- W2364943721 title "Expression and significance of TNF-related apoptosis inducing ligand and death receptor-5 in atherosclerosis rabbits" @default.
- W2364943721 hasPublicationYear "2007" @default.
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