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- W2364947568 abstract "To investigate protective efficacy of the fowlpox virus vaccine co-expressing infectious bronchitis virus (IBV) S1 gene and chicken interferon-γ gene (rFPV-IFNγ S1), four-week old SPF chickens were inoculated with rFPV-IFNγ S1 vaccine and challenged with IBV field strain LHLJ04XI and parental IBV LX4 three weeks post-inoculation. The results showed that chickens immunized with rFPV-IFNγ S1 developed IBV specific serum antibodies one week after immunization. The immunized chickens showed less pathological changes and shorter period of virus shedding, with less than 10 % motality after challenged with LHLJ04XI and parental IBV LX4. In contrast, the control group showed 100 % (11/11) morbidity and 45.5 % (5/11) mortality. Bodyweight analysis showed a higher weight gains for chickens in the immunized group. In conclusion, rFPV-IFNγ S1 could effectively induce protection against heterologous IBV field strain LHLJ04XI challenge, and alleviate the affect of recombinant virus immunization on chicken weight gains." @default.
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- W2364947568 date "2008-01-01" @default.
- W2364947568 modified "2023-09-26" @default.
- W2364947568 title "Protection of chickens against IBV field strain with a recombinant fowlpox virus co-expressing IBV S1 gene and ChIFNγ gene" @default.
- W2364947568 hasPublicationYear "2008" @default.
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