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- W2364947587 abstract "OBJECTIVE To determine the protective effect of montelukast sodium,a leukotriene antagonist,on myocardial necrosis in rats.METHODS The model of myocardial ischaemia and necrosis in rats induced by injected isoproterenol (2 mg·kg -1,sc,qd for 2 d) was used.The serum activity of AST,LDH,CK,MDA,and content of NO in myocardium and scope of myocardial necrosis were detected.RESULTS After pretreated with montelukast sodium 10.0 and 30.0 mg·kg -1,it was decreased the serum levels of LDH,CK and MDA,and attenuated myocardial necrosis area.Montelukast sodium 30 mg·kg -1 group also enhanced the content of NO in myocardium.CONCLUSION Montelukast sodium had the protective effect on myocardial necrosis in rats,this may represent an approach to the treatment of myocardial ischaemia with leukotriene antagonists." @default.
- W2364947587 created "2016-06-24" @default.
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- W2364947587 date "2003-01-01" @default.
- W2364947587 modified "2023-09-25" @default.
- W2364947587 title "Protective effect of montelukast sodium on isoproterenol-induced myocardial necrosis in rats" @default.
- W2364947587 hasPublicationYear "2003" @default.
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