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- W2364952513 abstract "Aim:To observe whether insulin can enhance chemotherapeutic response of 5-fluorouracil(5-FU) and study the significance of serum insulin-like growth factor-1(IGF-1) level in the enhancement.Methods:A total of 60 nude mice transplanted H22 liver cancer were built and randomly divided into 6 groups:control group,high dose insulin alone group,5-FU alone group,and 5-FU+high,medium,low dose insulin(4.5,3.0,1.5 U/kg) groups.5-FU was given at 10 mg/kg body mass intraperitoneally.Each mouse was injected a corresponding dosage once a day for 8 d.The rate of tumor inhibition was calculated.Serum IGF-1 and insulin-like growth factor binding protein-3(IGFBP-3) were determined by using ELISA methord.Results:There was significant difference on the inhibition rate of tumor growth among four groups(F=71.410,P0.001).The inhibition rate of tumor growth in high dosage of insulin+5-FU group was(51.35±3.14)%,which was significantly higher than(27.93±2.35)% in 5-FU alone group(P0.05).There was significant difference on serum IGF-1 level among four groups(F=13.720,P0.001).Serum IGF-1 level in high dose insulin+5-FU group [(492.13±58.88) μg/L] was significantly lower than that in 5-FU alone group [(595.51±260.77) μg/L](P0.05).Conclusion:Insulin could enhance chemotherapeutic response of 5-FU in nude mice with transplanted H22 liver cancer.The decreasing level of serum IGF-1 may play an important role in the enhancement of insulin on 5-FU." @default.
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- W2364952513 date "2009-01-01" @default.
- W2364952513 modified "2023-09-24" @default.
- W2364952513 title "Enhancement of chemotherapeutic response of insulin on 5-fluorouracil in nude mice with transplanted H22 liver cancer" @default.
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