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- W2364961204 abstract "Biodegradable material poly (lactic acid-glycolic acid) (PLGA) was directly synthesized via melt polycondensation. The poly (lactic acid-glycolic acid) synthesized was applied in Interferon-α microspheres. The optimal conditions for the preparation of Interferon-α microspheres were determined with orthogonal test. The characters of microspheres were examined. Starting from D,L-lactic acid and glycolic acid, catalyzed by SnCl_2, under 165 ℃ and 70 Pa, PLGA with the highest intrinsic viscosity (0.2382) dL/g was produced. Microspheres formed are spherical with smooth surfaces. The average particle size is (10.71) μm. Drug is enveloped in microspheres without mixing physically with PLA. The drug loading and the encapsulation efficiency of Interferon-α microspheres is (8.06%) and (36.97%) respectively. Interferon-α PLGA microspheres were successfully prepared." @default.
- W2364961204 created "2016-06-24" @default.
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- W2364961204 date "2005-01-01" @default.
- W2364961204 modified "2023-09-27" @default.
- W2364961204 title "STUDIES ON THE DIRECT SYNTHESIS OF POLY (LACTIC ACID-GLYCOLIC ACID) AND ITS APPLICATION IN DRUG DELIVERY MICROSPHERES" @default.
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