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- W2364961231 abstract "Objective To prepare sustained-release tablets of indapamide and investigate its release in vitro.Methods HPLC was employed to determine indapamide compared with imported products,evaluating different fillers(lactose,starch and MCC) and HPMC K4M percentage in formulations on accumulative release,and similarity analysis was performed between them.Results Lactose as the filler,HPMC K4M is at 25% in the formulation,the self-made tablets have a similar release profile with reference tablets.It is linear with concentration range from 0.2 μg·mL-1 to 1.5 μg·mL-1.The recovery rates of three different concentrations(low concentration,middle concentration and high concentration) were 100.08%、99.67%、99.58% respectively.Conclusion The preparation method is simple and economical.The self-made sustained-release tablets have the similar drug release characteristics with the reference tablets." @default.
- W2364961231 created "2016-06-24" @default.
- W2364961231 creator A5060330489 @default.
- W2364961231 date "2010-01-01" @default.
- W2364961231 modified "2023-09-23" @default.
- W2364961231 title "Preparation and release of indapamide sustained-release tablets in vitro" @default.
- W2364961231 hasPublicationYear "2010" @default.
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