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- W2364961802 abstract "Objective;To assess the toxicity of erythromycin stinoprate in cardiovascular,respir- atory and nervous system in rats and mice.Methods;Healthy SD rats were randomized to administer ei- ther erythromycin stinoprate 0,75,150 or 300 mg·kg~(-1) by duodenum.The blood pressure,ECG.breath rates and intensity were monitored.Additional mice were randomly administered with one of four oral do- ses of erythromycin stinoprate 0,75,150 or 300 mg·kg~(-1).The general activities and sleeping period were monitored.Results;Only erythromyein stinoprate 300 mg·kg~(-1)was found to reduce the heart rate of rats,and not to have significant effects on the blood pressure,ECG and breath rate and intensity.No sig- nificant effects on the general activity and sleeping period of mice were found.Conclusion;Erythromycin stinoprate 300 mg·kg~(-1) was significantly toxic on the cardiovascular system of rats." @default.
- W2364961802 created "2016-06-24" @default.
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- W2364961802 date "2006-01-01" @default.
- W2364961802 modified "2023-09-24" @default.
- W2364961802 title "The safety evaluation of erythromycin stinoprate" @default.
- W2364961802 hasPublicationYear "2006" @default.
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