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- W2364963476 abstract "Objective It is to discuss the expression of NF-KB in C7—L4 spinal ganglia of CIA rats and possible mechanism of acupuncture JiaJi points(C7—L4) on rheumatoid arthritis(RA).Methods CIA model was established.The expression of NF-KB proteinum in spinal ganglia was detected with immunohistochemical method.The changes of NF-KB in cell nucleus proteinum of spinal ganglia and arthrocele index of CIA rats were analyzed with Western blotting method.Results In control group,NF-KB of immunity positive was found mainly in cytoplasm and less in nucleus,its proteinum was expressed slightly in C7—L4 spinal ganglia and without arthroncus.In CIA group,NF-KB of immunity positive was showed shifting phenomenon.The proteinum expression level and arthrocele degree in CIA group were obviously higher than that in control group(P0.01).NF-KB of immunity positive in cytoplasm of C7—L4 spinal ganglia in acupuncture JiaJi points group was higher than that in nucleus.The proteinum expression level of nucleus in acupuncture JiaJi points group was lower than that in CIA group(P0.01) and there was no significant difference compared with control group(P0.05).There was no significant difference on arthrocele index between acupuncture JiaJi points group and control group(P0.05).Conclusion NF-KB activation in spinal ganglia participates in RA pathogenesis.Acupuncture JiaJi points inhibiting NF-KB expression and activation through inhibiting NF-KB signal transduction pathway and through neuroendocrine-immune network maybe one mechanism of acupuncture on RA." @default.
- W2364963476 created "2016-06-24" @default.
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- W2364963476 date "2007-01-01" @default.
- W2364963476 modified "2023-09-25" @default.
- W2364963476 title "Expression of NF-KB in spinal ganglia of CIA rats and therapeutic action of acupuncture Jiaji points" @default.
- W2364963476 hasPublicationYear "2007" @default.
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