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- W2364966461 abstract "Objective To explore the influnce of clozapine,risperdal,ziprasidone three antipsychotic drugs on patients with schizophrenia treatment process blood drug concentration and weight and the lipid metabolism.Methods Totally 187 cases of schizophrenia patients in accord with CCMD-3 schizophrenia diagnosis standard were randomly divided into clozapine,risperdal,ziprasidone three group,who were given single drug treatment for 6 months.In the treatment,and treatment before 1,2,3 and 6 months end monitor patients blood drug concentration(PDL),total cholesterol in the blood fat(TC),triglycerides(TG),high-density lipoprotein(HDL),low density lipoprotein(LDL),and other indicators,and at the same time with the positive and negative symptoms scale(PANSS) to assess the clinical symptoms and curative effect.Results After treatment compared with that before treatment,clozapine group,risperidone groups with blood drug concentration in the treatment of range increased blood fat and the index increased value,and in weight,TC item,a statistically significant difference(P0.05);Clozapine group(TG,LDL),risperidone groups TG with significant difference(P0.01).Ziprasidone group with blood drug concentration increase in the treatment of range,weight and the index of blood lipid before and after treatment was not statistically significant difference(P0.05).Conclusions Clozapine,risperdal blood drug concentration in the treatment of patients with increased within the scope of the weight and blood lipid metabolism all have influence,and the influence of clozapine more than risperdal;Ziprasidone blood drug concentration in the treatment of patients with increased within the scope of the weight and blood lipid metabolic effect is not obvious." @default.
- W2364966461 created "2016-06-24" @default.
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- W2364966461 date "2012-01-01" @default.
- W2364966461 modified "2023-09-28" @default.
- W2364966461 title "Research on influnce of Ziprasidone and clozapine risperdal in treatment of patients with schizophrenia,blood drug concentration and lipid metabolism" @default.
- W2364966461 hasPublicationYear "2012" @default.
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