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- W2364971440 abstract "Objective To explore the pathological basis of high altitude cerebral edema(HACE) by studying changes in diffusion-weighted imaging(DWI)and pathology of cerebral edema during hypoxia. Method Thirty-two Wistar rats (weighted 320~380 g) were randomly divided into normoxic group, 4 000 m group, 6 000 m group and 8 000 m group (n=8 for each group). Rats in the latter three groups were placed in hypobaric chamber to simulate the hypoxic environment at 4 000 m, 6 000 m, 8 000 m altitude above sea level for 8 h, respectively. Brains of all the rats were observed by DWI and examined with light and electronic microscopes. Result In the three hypoxic groups, signals of the lower intensity were found in DWI, and apparent diffusion coefficient (ADC) value was increased. There was no significant difference between ADC values of normoxic group and 4 000 m group, while ADC value was increased significantly in 6 000 m group and 8 000 group. Pathologic change of cytotoxic and vasogenic brain edema and damage in blood-brain barrier (BBB) were found in 4 000 m group and the vasogenic brain edema and the damage in BBB were much more serious in 6 000 m group. Severe vasogenic brain edema was found and the BBB disintegrated thoroughly in 8 000 m group. Conclusion Brain edema during hypoxia is mainly vasogenic brain edema (VBE) and the pathological basis is BBB damaged." @default.
- W2364971440 created "2016-06-24" @default.
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- W2364971440 date "2005-01-01" @default.
- W2364971440 modified "2023-09-26" @default.
- W2364971440 title "Observation of Diffusion Weighted MRI and Pathology of Cerebral Edema during Hypoxia" @default.
- W2364971440 hasPublicationYear "2005" @default.
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