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- W2364972013 abstract "Objective To understand the toxicity and biocompatibility of chitosan antibacterial spray in order to assess its safety.Methods Animal test and cytotoxicity test in vitro were performed to evaluate the biological safety of this biological disinfectant.Results Chitosan antibacterial spray containing 1% chitosan had no significant effect on the L-929 cell morphology and had no significant inhibition on cell growth and proliferation;The cytotoxicity gradation was 0 degree in various concentration of leaching liquors of test materials.Mild irritation was found in vaginal mucosa of rabbit,vas congestion was found in pathological test and irritation index was 1.44 which belonged to mild irritation grade.No skin erythema and edema was found in albinism animal test,which belonged to no-hypersensitivity.Conclusion This chitosan antibacterial spray used for mucosa has mild stimulation,good biocompatibility and biological safety." @default.
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- W2364972013 date "2012-01-01" @default.
- W2364972013 modified "2023-09-25" @default.
- W2364972013 title "BIOLOGICAL SAFETY EVALUATION OF CHITOSAN ANTIBACTERIAL SPRAY" @default.
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