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- W2364977566 abstract "2-amino-3H-pyrrolo[2,3d]pyrimidin-4(7H)-one is an important pharmaceutical intermediate.Starting material cyanoethyl acetate was alkylated,and followed by subsequent ring closures to yield the targeting product 3.It was concluded from the experiment that potassium carbonate as a base worked best in the deprotonation of cyanoethyl acetate;the optimal reaction time for the synthesis of intermediate 2 was 2.5 hours,and application of protective atmosphere in this step obviously demonstrated beneficial effect;the optimal percentage concentration of hydrochloric acid was 12% in the process of generating the final product.The overall yield of the whole syntheses was 6.4%.Structures of the products were characterized by NMR spectroscopy,elementary analysis and melting point measurement." @default.
- W2364977566 created "2016-06-24" @default.
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- W2364977566 date "2010-01-01" @default.
- W2364977566 modified "2023-09-23" @default.
- W2364977566 title "Synthesis of Fused Ring Nitrogen Containing Pharmaceutical Intermediate 2-Amino-3H-Pyrrolo[2,3d]Pyrimidin-4(7H)-One" @default.
- W2364977566 hasPublicationYear "2010" @default.
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