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- W2364981010 abstract "Objective To evaluate the incidence of gene polymorphism of coagulation factor V and activatedprotein C-resistance(APC-R)and lupus anticoagulant (LA) in patients with thrombophilia. Methods APC-R, LAand FV G1691→G, A1090→G gene polymorphism were assasyed in 237 patients with thrombophilia and 60 nor-mal subjects. Results There were 41 positive for LA (45.6%), 3 positive for APC-R(3.3%)in patients with Cere-bral infarct; 24 positive for LA(40.7%), 0 positive for APC-R in patients with Coronary heart disease; 22 posi-tive for LA (38.6%), 4 positive for APC-R(7.0%) in patients with high blood pressure; 13 positive for LA(41.9%), 1 positive for APC-R (3.2%), in patients with deep vein thrombosis. There were no positive for LAand APC-R in the control subjects. There were no FV G1691→A, G1091→C, A1090→G gene mutation in pa-tients with thrombophilia. Conclusion There were especially high positive LA rate and perhaps LA is one ofthe important causes of thrombosis in patients with thrombophilia. There were APC-R phenomenon in patientswith thrombophilia, perhaps having no relationship with factor V gene mutation." @default.
- W2364981010 created "2016-06-24" @default.
- W2364981010 creator A5073595838 @default.
- W2364981010 date "2004-01-01" @default.
- W2364981010 modified "2023-09-23" @default.
- W2364981010 title "The analysis of coagulation factor V G1691→A, G1091→G gene polymorphism, APC-R and LA in patients with thrombophilia" @default.
- W2364981010 hasPublicationYear "2004" @default.
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