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- W2364983742 abstract "Objective To discuss the influences of Tangmoning Granules on the expressions of sciatic nerve growth factor(NGF) and insulin-like growth factor-1(IGF-1) proteins in rats with diabetic peripheral neuropathy(DPN).Methods Wistar rats(n=36) were randomly divided into the normal group,model group and Tangmoning Granules group.The rat model of diabetes was established by the injection of 2% streptozotocin(STZ,53 mg/kg).The diabetic rats were given orally the suspension of Tangmoning Granules(2.3 g/kg) every day during test.The sciatic ultrastructure was observed by using transmission electron microscope(TEM),and the expressions of sciatic NGF and IGF-1 proteins were detected by applying Western blot method and immunohistochemistry in all groups.Results The expressions of sciatic NGF and IGF-1 proteins were lower in the model group than those in the normal group,and those in the Tangmoning Granules group was higher than those in the model group but lower than those in the normal group.The result of TEM showed that Tangmoning Granules relieved the pathological changes of rat sciatic nerve.Conclusion Tangmoning Granules has some protective effect on sciatic nerve in diabetic rats.The mechanism may be related to the up-regulation of the expressions of NGF and IGF-1 proteins." @default.
- W2364983742 created "2016-06-24" @default.
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- W2364983742 date "2010-01-01" @default.
- W2364983742 modified "2023-09-24" @default.
- W2364983742 title "Influences of Tangmoning Granules on sciatic expressions of NGF and IGF-1 proteins in rats with diabetic peripheral neuropathy" @default.
- W2364983742 hasPublicationYear "2010" @default.
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