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- W2364986105 abstract "Objective:To investigate the expression of heparanase and matrix metalloproteinase-9(MMP-9) ,and their correlations with the metastasis and prognosis of pancreatic carcinoma. Methods:Immunohistochemical staining(SP method) was used to measure HPA and MMP-9 expression in 92 cases of pancreatic carcinoma,24 cases of chronic pancreatitis(CP) and 10 cases of normal pancreas. Correlations of the expression of HPA and MMP-9 to clinicopathologic features were analyzed. Pearson rank correlation was used to analyze. Results:The expression of HPA in pancreatic carcinoma was significantly higher than that in chronic pancreatitis and normal pancreas(77.2%,25.0%,0,P0.05) . The HPA protein intensive expression was positively correlated with the infiltration of other tissue and lymph node metastasis(P0.05) ,whereas it was negatively correlated with gender,age,histological grade and 1-year postoperative survival(P0.05);the expression of MMP-9 in pancreatic carcinoma was significantly higher than that in chronic pancreatitis and normal pancreas(70.0%,20.8%,20.0%,P0.05) . The MMP-9 protein intensive expression was correlated with the infiltration of other tissue and lymph node metastasis(P0.05) ,whereas it was negatively correlated with gender,age,tumor differentiation and 1-year postoperative survival(P0.05) . HPA and MMP-9 expression had a higher positive rate in pancreatic carcinoma(P=0.018) . The positive expression of HPA and MMP-9 is correlated in the pancreatic carcinoma(r=0.729,P0.05) . Multivariate analysis showed that neither HPA nor MMP-9 was the independent prognostic factor. Conclusion:HPA and MMP-9 may be associated with the infiltration and metastasis of the pancreatic carcinoma. HPA and MMP-9 may be important features of cancer of pancreatic. A combined detection of them may benefit us in prediction of the progression of pancreatic carcinoma. MMP-9 may up-regulate HPA expression and promote HPA-dependent tumor infiltration and metastasis." @default.
- W2364986105 created "2016-06-24" @default.
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- W2364986105 date "2010-01-01" @default.
- W2364986105 modified "2023-10-17" @default.
- W2364986105 title "HPA and MMP-9 in the expression of invasion and metastasis of pancreatic cancer and clinical significance" @default.
- W2364986105 hasPublicationYear "2010" @default.
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