Matches in SemOpenAlex for { <https://semopenalex.org/work/W2364990179> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W2364990179 abstract "Objective To investigate the apoptosis of type Ⅱ alveolar epithelial cells(AECⅡ) in rat model of chronic obstructive pulmonary disease(COPD) and observe the effects of inhaled glucocorticoid on AECⅡ apoptosis.Methods A rat model of COPD was established by tobacco smoke inhalation and intratracheally administered lipopolysaccharide.Forty-eight rats were randomly divided into eight groups,ie.a sam control group,a budesonide(BUD)control group,a 15-days group of COPD,a 15-days group with low dose BUD,a 15-days group with high dose BUD,a 30-days group of COPD,a 30-days group with low dose BUD and a 30-days group with high dose BUD.The rats were sacrificed on 15th and 30th day respectively to obtain the pulmonary tissue.The degree of alveolar destruction was observed by HE stain and the apoptosis of AECⅡ was detected by immunohistochemistry and TUNEL methods.Results The degree of alveolar destruction and the apoptosis of AECⅡ were significantly increased in COPD rats in a time-dependent manner than those in the BUD and sam control groups(both P0.01) with a significantly positive correlation between each other(P0.01),Inhaled glucocorticoid could decrease the degree of alveolar destruction(P0.01) and the apoptosis of AECⅡ in COPD rats significantly(P0.01)in a dose-dependent manner.Conclusion The apoptosis of AECⅡ may be involved in the pathological process of COPD through alveolar destruction,and inhaled glucocorticoid can prevent alveolar destruction and the apoptosis of AECⅡ in COPD rats,which provide futher evidence for inhaled glucocorticoid in COPD treatment." @default.
- W2364990179 created "2016-06-24" @default.
- W2364990179 creator A5051308309 @default.
- W2364990179 date "2007-01-01" @default.
- W2364990179 modified "2023-09-24" @default.
- W2364990179 title "Apoptosis of type II alveolar epithelial cells in rat model of chronic obstructive pulmonary disease and the effects of inhaled glucocorticoid" @default.
- W2364990179 hasPublicationYear "2007" @default.
- W2364990179 type Work @default.
- W2364990179 sameAs 2364990179 @default.
- W2364990179 citedByCount "0" @default.
- W2364990179 crossrefType "journal-article" @default.
- W2364990179 hasAuthorship W2364990179A5051308309 @default.
- W2364990179 hasConcept C126322002 @default.
- W2364990179 hasConcept C134018914 @default.
- W2364990179 hasConcept C142724271 @default.
- W2364990179 hasConcept C190283241 @default.
- W2364990179 hasConcept C196795494 @default.
- W2364990179 hasConcept C204232928 @default.
- W2364990179 hasConcept C2776136866 @default.
- W2364990179 hasConcept C2776780178 @default.
- W2364990179 hasConcept C2776954882 @default.
- W2364990179 hasConcept C2777714996 @default.
- W2364990179 hasConcept C2780841215 @default.
- W2364990179 hasConcept C42219234 @default.
- W2364990179 hasConcept C55493867 @default.
- W2364990179 hasConcept C71924100 @default.
- W2364990179 hasConcept C86803240 @default.
- W2364990179 hasConceptScore W2364990179C126322002 @default.
- W2364990179 hasConceptScore W2364990179C134018914 @default.
- W2364990179 hasConceptScore W2364990179C142724271 @default.
- W2364990179 hasConceptScore W2364990179C190283241 @default.
- W2364990179 hasConceptScore W2364990179C196795494 @default.
- W2364990179 hasConceptScore W2364990179C204232928 @default.
- W2364990179 hasConceptScore W2364990179C2776136866 @default.
- W2364990179 hasConceptScore W2364990179C2776780178 @default.
- W2364990179 hasConceptScore W2364990179C2776954882 @default.
- W2364990179 hasConceptScore W2364990179C2777714996 @default.
- W2364990179 hasConceptScore W2364990179C2780841215 @default.
- W2364990179 hasConceptScore W2364990179C42219234 @default.
- W2364990179 hasConceptScore W2364990179C55493867 @default.
- W2364990179 hasConceptScore W2364990179C71924100 @default.
- W2364990179 hasConceptScore W2364990179C86803240 @default.
- W2364990179 hasLocation W23649901791 @default.
- W2364990179 hasOpenAccess W2364990179 @default.
- W2364990179 hasPrimaryLocation W23649901791 @default.
- W2364990179 hasRelatedWork W1739826300 @default.
- W2364990179 hasRelatedWork W2021629309 @default.
- W2364990179 hasRelatedWork W2029097275 @default.
- W2364990179 hasRelatedWork W2143276516 @default.
- W2364990179 hasRelatedWork W2346126139 @default.
- W2364990179 hasRelatedWork W2348903797 @default.
- W2364990179 hasRelatedWork W2348922968 @default.
- W2364990179 hasRelatedWork W2352030391 @default.
- W2364990179 hasRelatedWork W2354671207 @default.
- W2364990179 hasRelatedWork W2364800858 @default.
- W2364990179 hasRelatedWork W2369307741 @default.
- W2364990179 hasRelatedWork W2369677776 @default.
- W2364990179 hasRelatedWork W2369831248 @default.
- W2364990179 hasRelatedWork W2391407483 @default.
- W2364990179 hasRelatedWork W2393470878 @default.
- W2364990179 hasRelatedWork W2402991194 @default.
- W2364990179 hasRelatedWork W2511955406 @default.
- W2364990179 hasRelatedWork W3031063950 @default.
- W2364990179 hasRelatedWork W3031210396 @default.
- W2364990179 hasRelatedWork W3032572634 @default.
- W2364990179 isParatext "false" @default.
- W2364990179 isRetracted "false" @default.
- W2364990179 magId "2364990179" @default.
- W2364990179 workType "article" @default.