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- W2364995791 abstract "Objective To investigate the effect and mechanism of WuZiYanZong pill(WZYZ) on chemotherapy sensitivity and chemotherapy related fatigue(CRF) in mice.Methods BALB/c mouse models of breast cancer were prepared by 4T1 cell inoculation and randomized into the TC group,the paclitaxel(PTX) group,the WZYZ group,and the WZYZ+PTX group,respectively.After 21 days treatment,all mice were sacrificed and used for determinations of SOD and MDA in muscle and organ indexes.Results The swimming abilities of mice in the WZYZ+PTX group and the WZYZ group were significantly enhanced.Compared with the TC group,the tumor weight in WZYZ+PTX and PTX was significantly lighter,and the tumor volume in WZYZ +PTX was significantly smaller.Compared with the PTX group,the thymus index of mouse and the SOD level were significantly increased,and the MDA level was significantly decreased in the WZYZ group and WZYZ+PTX group.Conclusions WZYZ could efficiently enhance the chemotherapy sensitivity of PTX and alleviate the CRF.The immune regulation and antioxidant effect of WZYZ may contribute to the antitumor ability of WZYZ." @default.
- W2364995791 created "2016-06-24" @default.
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- W2364995791 date "2013-01-01" @default.
- W2364995791 modified "2023-09-27" @default.
- W2364995791 title "Effects of WuZiYanZong pill on chemotherapy sensitivity and chemotherapy associated fatigue in mice" @default.
- W2364995791 hasPublicationYear "2013" @default.
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