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- W2364997007 abstract "Objective To explore whether ginkgo biloba extract(EGB761)could partially protect embryonic rat mesencephalic dopaminergic(DAergic)neurons injured by MPP+.Methods Embryonic rat mesencephalic primary cell culture method was used to isolate and culture the mesencephalic neurons,and the cultured cells were randomized into groups of control(group 1),MPP+(group 2),MPP++EGB761(group 3),MPP++LPS(group 4),and MPP++EGB761+LPS(group 5).The cells were intervened with MPP+,EGB761 and LPS to observe cell growth.Cytoactive was detected by microcolorimetry of 3-(4,5-dimethyl-thiazole-2)-2,5-diphenyl-tetrazolium Bromine-salt(MTT),changes of positive neurons and DA neuron expression by tyrosine hydroxylase(TH) immunofluorescence(FITC),and nitric oxide expression in cultured cells by nitric acid reduction method.Results Strong growth and significantly extended axons was noted in groups 1 and 3;inhibited cell growth and relatively short axons in group 5;a small number of cells,only a few cells with small cell processes,but most without in 2 and 4.By MTT method,cell absorbance ratio(A value),expressions of immunofluorescence TH positive cells and of cultured cell NO were detected:groups 1,3 differed significantly from groups 5,2,4 in NO level(P0.05),and group 5 from group 2,4(P0.05),group 2 from group 4(P0.05).Conclusion LPS can increase MMP +-injured DA neuron,microglia activation and the NO which it released may participate in the process of the cell apoptosis.EGB 761 may play a protective role in injured primary cultured brain cells of embryo rats,which may inhibit microglia to activate." @default.
- W2364997007 created "2016-06-24" @default.
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- W2364997007 date "2011-01-01" @default.
- W2364997007 modified "2023-09-26" @default.
- W2364997007 title "Effects of EGB761 on Primary Cultures of Embryonic Rat Mesencephalic Cells Injured by MPP" @default.
- W2364997007 hasPublicationYear "2011" @default.
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