Matches in SemOpenAlex for { <https://semopenalex.org/work/W2364999534> ?p ?o ?g. }
Showing items 1 to 55 of
55
with 100 items per page.
- W2364999534 abstract "Objective To observe the effects of β-Aescinate on expression of interleukin-1β(IL-1β),aquaporin 4(AQP4) in brain tissue and volume of cerebral infarct and edema in mice with cerebral ischemic(CI). Methods Two hundred and thirty-seven mice were randomly divided into sham-operation group(n=48),CI group(n=63),β-Aescinate group(n=63) and normal saline(NS) control group(n=63).Every group was divided into 5 subgroups after ischemia 12 h,24 h,48 h,72 h and 168 h.The middle cerebral artery occlusion(MCAO)CI model was induced by thread embolism method.Two hours after MCAO,β-Aescinate and same volume NS were injected via abdominal cavity in the β-Aescinate group and NS control group respectively,and once in every 24 h.Brain water content(Dry/Wet method),infarct volume(TTC Stain),and expression of IL-1β and AQP4 in brain tissue(Enzyme-linked immunosorbent assay) were detected at correspoding time points after MCAO. Results Compared with sham-operation group,the brain water content were significantly increased,the expression of IL-1β and AQP4 in brain tissue were significantly upregulated at different points after CI in CI group and NS control group(P0.05-0.01).The brain water content,infarct volumes and expression of IL-1β and AQP4 in brain tissue in β-Aescinate group were significant lower than those in CI group and NS control group(P0.05-0.01). Conclusion β-Aescinate can inhibit the expression of IL-1β and AQP4 in brain tissue and reduce brain injury and edema after CI." @default.
- W2364999534 created "2016-06-24" @default.
- W2364999534 creator A5023512298 @default.
- W2364999534 date "2011-01-01" @default.
- W2364999534 modified "2023-09-27" @default.
- W2364999534 title "Effects of β-Aescinat on expression of interleukin-1β,aquaporin 4 in brain tissue and volume of cerebral infarct and edema in mice with cerebral ischemic" @default.
- W2364999534 hasPublicationYear "2011" @default.
- W2364999534 type Work @default.
- W2364999534 sameAs 2364999534 @default.
- W2364999534 citedByCount "0" @default.
- W2364999534 crossrefType "journal-article" @default.
- W2364999534 hasAuthorship W2364999534A5023512298 @default.
- W2364999534 hasConcept C126322002 @default.
- W2364999534 hasConcept C142724271 @default.
- W2364999534 hasConcept C15755913 @default.
- W2364999534 hasConcept C2779493303 @default.
- W2364999534 hasConcept C2986936838 @default.
- W2364999534 hasConcept C42219234 @default.
- W2364999534 hasConcept C541997718 @default.
- W2364999534 hasConcept C71924100 @default.
- W2364999534 hasConceptScore W2364999534C126322002 @default.
- W2364999534 hasConceptScore W2364999534C142724271 @default.
- W2364999534 hasConceptScore W2364999534C15755913 @default.
- W2364999534 hasConceptScore W2364999534C2779493303 @default.
- W2364999534 hasConceptScore W2364999534C2986936838 @default.
- W2364999534 hasConceptScore W2364999534C42219234 @default.
- W2364999534 hasConceptScore W2364999534C541997718 @default.
- W2364999534 hasConceptScore W2364999534C71924100 @default.
- W2364999534 hasLocation W23649995341 @default.
- W2364999534 hasOpenAccess W2364999534 @default.
- W2364999534 hasPrimaryLocation W23649995341 @default.
- W2364999534 hasRelatedWork W2357592914 @default.
- W2364999534 hasRelatedWork W2370396300 @default.
- W2364999534 hasRelatedWork W2376077213 @default.
- W2364999534 hasRelatedWork W2400795456 @default.
- W2364999534 hasRelatedWork W2409361708 @default.
- W2364999534 hasRelatedWork W2496114186 @default.
- W2364999534 hasRelatedWork W2746353962 @default.
- W2364999534 hasRelatedWork W279221595 @default.
- W2364999534 hasRelatedWork W2979170657 @default.
- W2364999534 hasRelatedWork W3028707983 @default.
- W2364999534 hasRelatedWork W3029452653 @default.
- W2364999534 hasRelatedWork W3029898432 @default.
- W2364999534 hasRelatedWork W3030617750 @default.
- W2364999534 hasRelatedWork W3030779649 @default.
- W2364999534 hasRelatedWork W3030889554 @default.
- W2364999534 hasRelatedWork W3031590995 @default.
- W2364999534 hasRelatedWork W3031667240 @default.
- W2364999534 hasRelatedWork W3032195284 @default.
- W2364999534 hasRelatedWork W3032428279 @default.
- W2364999534 hasRelatedWork W3141689662 @default.
- W2364999534 isParatext "false" @default.
- W2364999534 isRetracted "false" @default.
- W2364999534 magId "2364999534" @default.
- W2364999534 workType "article" @default.