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- W2365001537 abstract "To investigate the variation of expression levels of selected Melanoma Associated Antigen superfamily members during the process of MCF-7 cell differentiation and apoptosis induced by all-trans retinoic acid, thus providing valuable information for the function of the MAGE family members is presented. Six-well plate cultured breast cancer cell line MCF-7 cells were treated in exponential phase with ATRA at concentration of 10 -6 mol/L. Cells were harvested for detection of the expression of MAGE super-family (MAGE-A1,MAGE-C1, MAGE-D1,Necdin) by RT-PCR at different time(0 h,12 h,18 h,24 h,36 h,48 h)after treatment. The expression of acid MAGE subfamily members included (typeⅠantigen) were downregulated gradually under the induction of ATRA with time going, while the selected alkali MAGE subfamily (typeⅡantigen) members are in the opposite situation. It is condused that MAGE superfamily members possibly are involved in the process of MCF-7 cell differentiation and apoptosis induced by all-trans retinoic acid, and acid and alkali members in MAGE family may function in the opposite way." @default.
- W2365001537 created "2016-06-24" @default.
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- W2365001537 date "2006-01-01" @default.
- W2365001537 modified "2023-09-26" @default.
- W2365001537 title "Effects of All-trans Retinoic Acid on the Expression of Melanoma Associated Antigen Superfamily Members in MCF-7 Cells" @default.
- W2365001537 hasPublicationYear "2006" @default.
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