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- W2365002907 abstract "Objective To investigate the effects of different doses of vecuronium on ventilatory function and mechanics of breathing during elective laparoscopic cholecystectomy. Methods Sixty-three ASA Ⅰ - Ⅱ patients aged 29-57 yr were randomly divided into 3 groups of twenty-one: group Ⅰ received vecuronium 1 × ED95 , group Ⅱ 2 × ED95 and group Ⅲ 3 × ED95 . Patients with respiratory disease were excluded. The patients were premedicated with intramuscular scopolamine 0.3 mg and oral diazepam 0.1 mg· kg-1 . Anesthesia was induced with fentanyl 2μg· kg-1 , propofol 2 mg·kg-1 and succinylcholine 1.5 mg· kg-1 and maintained with 1.0%-1.5% isoflurance and intermittent iv boluses of propofol 1 mg·kg-1 when needed. Vecuronium 1 × ED95 (group Ⅰ ) or 2 × ED95 (group Ⅱ ) or 3 × ED93 ( group Ⅲ ) was given iv after succinylcholine when TOF showed that T1 70% . The patients were mechanically ventilated. VT was set at 10 ml· kg-1 and respiratory rate at 12 bpm. End-tidal PCO2 was maintained at 30-35 mm Hg. End-tidal PCO2, SpO2, ECG and BP were continuously monitored. The respiratory function and mechanics were measured using respiratory monitor CP-100 (BICORE) before and after pneumoperitoneum (intra-abdominal pressure reached 15 mm Hg) and 5,10,15,20,25,30,35 min after vecuronium. The respiratory parameters measured included inspiratory and expiratory VT ( VTi, VTe) , minute ventilation (VE), respiratory rate (RR), peak inspiratory and expiratory flow rate (PIFR,PEFR), PEEP, auto-PEEP, pressure-time product (PTP), inspiratory-time ratio (TI/TTOT ), rate/VT ratio, average airway pressure (PAWM), esophageal pressure (PES), peak inspiratory pressure (PIP), dynamic compliance (CDyn), airway resistance (RAw ) and work of breathing. Results There was no significant difference in the effect of different doses of vecuronium on respiratory function and mechanics including all parameters measured at all time points among the three groups. Mean airway pressure, esophageal pressure peak inspiratory pressure, airway resistance and work of breathing increased significantly but dynamic compliance decreased significantly after CO2 penumoperitoneum. Conclusion Intra-abdominal CO2 insufflation significantly attect respiratory mecnanics. me effect of pneumoperitoneum on respiratory mechanics can not be prevented or attenuated by increasing the dose of muscle relaxant." @default.
- W2365002907 created "2016-06-24" @default.
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- W2365002907 date "2003-01-01" @default.
- W2365002907 modified "2023-09-25" @default.
- W2365002907 title "The effect of different doses of vecuronium on respiratory function and mechanics during laparoscopic cholecystectomy" @default.
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