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- W2365008194 abstract "Objective:To study the relationship between Epstein Barr virus(EBV)and development of nasopharyngeal carcinoma(NPC)as well as pathological significance of EBV encoded small RNA A(EBER 1) expression.Methods:The expression and distribution of EBER 1 in paraffin embedded tissue from 50 cases of NPC were studied by in situ hybridization.Results:EBER 1 was not detected in normal and simple hyperplasia of nasopharyngeal epithelial cells and metaplasia of nasopharyngeal mucosal epithelia.Of the 50 cases of NPC,49 cases(98%)showed the expression of EBER 1 that was still present in metastatic NPC cells and dysplastic cells of paratumourous nasopharyngeal epithelium.Conclusion:There is a strong association between EBV and NPC,and EBV may play an important role in the pathogenesis of NPC.The dysplastic cells of nasopharyngeal epithelium especially those positive for EBER 1 can be regarded as a kind of precarcinomatous change.The measurement of EBER 1 may be helpful in screening early NPC in high risk populations." @default.
- W2365008194 created "2016-06-24" @default.
- W2365008194 creator A5030035445 @default.
- W2365008194 date "2000-01-01" @default.
- W2365008194 modified "2023-09-23" @default.
- W2365008194 title "QUANTITATIVE STUDY ON EBER 1 EXPRESSION DURING THE DEVELOPMENT OF NASOPHARYNGEAL CARCINOMA" @default.
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