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- W2365026119 abstract "Objective: To investigate the expression of adrenomedullin (ADM) in human breast cancer and evaluate the relationship with the clinical figure. Methods: The quatity of ADM gene protein expression was detected by flow cytometry in thirty-two cases of breast cancer, whose tissues were two centimeter and five centimeter away from distal tumor margin and ten fibroadenoma tissues. Results: The expressional level of ADM in breast cancer tissues was significontly higher(1.234 ± 0.456) than those in two centimeter away(1.011 ± 0.336, P 0.05)and five centimeter away (0.981 ± 0.397,P 0.05), and their difference had no statistical significance (P 0.05), the expression level of breast cancer was significenty higher than those in the fibroadenoma(0.930 ± 0.141,P 0.01). The expression level of ADM in the breast cancer was obviously related with the histological stage of tumor(rs= 0.552,P 0.01). The histological expression level of ADM in grading Ⅲ(1.516±0.579) was higher than those in grading Ⅱ(1.072 ± 0.186,P 0.01)and grading Ⅰ(0.956 ± 0.223,P 0.05).There was no significance statistical between grading Ⅱand grading Ⅰ(P 0.05). There wre no relationships between the expression level of ADM in cancer and tumor size, TNM stage, histological type, nodal status, EP/PR and c-erbB-2(P 0.05). Conclusion: The expression of ADM signifcantly increase in breast cancer and the worse histologial differentiation expression increase." @default.
- W2365026119 created "2016-06-24" @default.
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- W2365026119 date "2006-01-01" @default.
- W2365026119 modified "2023-09-26" @default.
- W2365026119 title "The Expression of Adrenomedullin in Breast Cancer and Its Relationship with Clinicopathological Factors" @default.
- W2365026119 hasPublicationYear "2006" @default.
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