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- W2365030255 abstract "Aim To investigate the changes of Ca~(2+)-activated K~+(KCa) channels of rats aortic smooth muscle cells with aging.Methods The aortic smooth muscle cells from rats of three groups(1,6,20 months,n=20 respectively) was digested by enzyme and studied the activity of KCa in the rats aortic smooth muscle cells by the Patch-clamp technique.The signal channel open probability(Po),open dwell-time(To),close dwell-time(Tc) and urrent ampitude(AM) were recorded.Results(1)The conductance of the rats aortic smooth muscle cells of 1,6,20 months was 192±47 ps,177±56 ps,163±35 ps respectively.There was no significant difference in each group(P0.05).But the AM of the rats aortic smooth muscle cells decresed with aging.(2)The Po of KCa in the rats aortic smooth muscle cells was 0.009±0.001,0.015±0.004 respectively,The Tc was 2260±653,2512±185 respectively in 20 month-old rats and in 1 month-old rats under inside-out patch.The activity of KCa had significant difference between two groups(P0.01).(3)The sensitity of KCa channel to Ca~(2+) in the aortic smooth muscle cells from different month-old rats: After adding ca~(2+)(5×10~(-7),10~(-6),10~(-5) mol/L) to cytoplasm,the Po incresed and the Tc decresed in each group.While comparison of different month-old rats,the Po and the To of 20 month-old rats was less than that of 6 month-old rats and 1 month-old rats.Conclusion The activity of KCa reduced in rats aortic smooth muscle with aging" @default.
- W2365030255 created "2016-06-24" @default.
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- W2365030255 date "2005-01-01" @default.
- W2365030255 modified "2023-09-25" @default.
- W2365030255 title "Research of Changement of Calcium-Activated Potassium Channels in Rat Aortic Smooth Muscle with Aging" @default.
- W2365030255 hasPublicationYear "2005" @default.
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