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- W2365033760 abstract "Objective To provide some messages for clinical comprehensive therapy. by investigating the changes of sex hormone levels and menstrual cycles in premenopausal patients with postoperative breast cancer treated with adjuvant chemotherapy. Methods The changes of oestrogen (E2), progestin (P), testosterone (T) in the serum of peripheral blood and menstrual cycles were analyzed by retrospective analyses and statistical methods in the process of adjuvant chemotherapy, in 97 premenopausal patients with postoperative breast cancer. The patients were divided into three groups according to patient's ages: group Ⅰ (12 cases, ≤30 years old), group Ⅱ (34 cases, 31～40 years old), and group Ⅲ (51 cases, ≥41 years old). Results Before the first chemotherapy, the levels of E2, P, T in serum of peripheral blood were (283.73 ± 53.12) pg/ml, (13.98 ± 5.67) ng/ml, and (48.64 ± 16.73) ng/dl in group Ⅰ, (278.86±59.36) pg/ml, (13.01±6.02) ng/ml, and (46.32±17.09) ng/dl in group Ⅱ, (243.11±90.) /ml, (14.01±6.45) ng/ ml, (43.89±18.88) ng/dl in group Ⅲ, respectively. There were no significant differences among the three groups (P 0.05). However, the levels of E2, P were significantly different with chemotherapy cycles (P0.01): the levels of E2, P gradually diminished with chemotherapy cycles. The T concentration did not changed with chemotherapy cycles (P 0.05). Total amenorrhoea rate was 41.2% after chemotherapy cycles were over. The levels of E2, P, T were (53.66± 47.91) pg/ml, (5.34±4.22) ng/ml, (43.32±22.04) ng/dl in unamenorrhoea group, (12.21±5.64) pg/ml, (0.5±0.2) ng/ml, (103.2±29.88) ng/dl and in amenorrhoea group, respectively. There were significant differences between unamenorrhoea group and amenorrhoea group (P0.01). The levels of E2, P both significantly reduced, and the T levels were higher in amenorrhoea group. Amenorrhoea rates and time happened amenorrhoea were not the same in different age groups. There was a positive linear correlation between amenorrhoea rates and ages (r=1, P=0.016), amenorrhoea rates were higher in older women than younger women. Time happened amenorrhoea showed negative linear correlation with ages (r=-0.99, P=0.031), which were earlier in older women than younger women. Conclusion In premeno-pausal patients with postoperative breast cancer, the levels of E2, P in serum of peripheral blood gradually diminish, and the T levels feedback rise during chemotherapy. Amenorrhoea happens when the levels of E2, P diminished to some degree." @default.
- W2365033760 created "2016-06-24" @default.
- W2365033760 creator A5042546741 @default.
- W2365033760 date "2013-01-01" @default.
- W2365033760 modified "2023-09-23" @default.
- W2365033760 title "Influence of adjuvant chemotherapy on sex hormone levels and menstrual cycles in premenopausal patients with postoperative breast cancer" @default.
- W2365033760 hasPublicationYear "2013" @default.
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