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- W2365047813 abstract "Objective: To compare the preventive and therapeutic effects of Danshen Injection and ligustrazine on kidney ischemia-reperfusion injury(IRI). Methods: Forty SD rats were randomly divided into four groups: Danshen Injection group, ligustrazine group, model group and sham-operation group. The first two groups were treated with Danshen Injection and ligustrazin respectively, the latter two groups were injected with normal saline. Kidney ischemia-reperfusion injury(IRI) model was established in three days as following: the artery and vein of the left kidney were clipped by an untrauma clamp for one hour, and subsequently, the right kidney was resected while the left kidney was reperfused. Serum creatinine(Scr) was measured at 6 hours and 24 hours after surgery respectively. MDA and SOD activity in the left kidney tissue were detected. And the histomorphology change in the left kidney was also assessed. Results: The contents of Scr at 6 h and 24 h after reperfusion in Danshen Injection group were not significantly different from those in model group, P 0.05. But They were higher than those in ligustrazine group and sham-operation group, P 0.01. The activity of SOD in the left kidney at 6 h, 24 h after reperfusion in the ligustrazine group was higher than that in Danshen Injection group, P 0.05. MDA detected in the kidney tissue at 6 h after reperfusion in Danshen Injection group was similar to that in the ligustrazine group, but it was much higher in the Danshen Injection group than in the ligustrazine group 24 h after reperfusion, P 0.01. The results from the pathological examination indicated that there was much more necrosis in the renal tubular in model group than in Danshen Injection group, and the necrosis improved significantly in ligustrazine group. Conclusion: Ligustrazine has an obvious preventive and therapeutic effect on kidney IRI, which may partly due to antioxidation, while Danshen Injection has no such effect." @default.
- W2365047813 created "2016-06-24" @default.
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- W2365047813 date "2007-01-01" @default.
- W2365047813 modified "2023-09-28" @default.
- W2365047813 title "Comparative Study of Effects of Danshen Injection and Ligustrazine on Kidney Ischemia-reperfusion Injury" @default.
- W2365047813 hasPublicationYear "2007" @default.
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