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- W2365054617 abstract "Objective To investigate the effect of shear stress on the expression of c-fos and c-myc mRNA in cultured human retinal pigment epithelial(RPE) cells.Methods RPE cells were exposed to shear stress of 2 dyne/cm2 for 0,0.25,0.5,0.75,1,1.5,and 3 h.Reverse transcription polymerase chain reaction(RTPCR) was used to detect the levels of c-fos and c-myc mRNA in RPE cells.One-way analysis of variance was used to compare the differences.Results After exposure to shear stress for 0.75 h,the morphology of the RPE cells began to change:paracellular spaces widened,cells were deformed and detached.After exposure to shear stress for more than 1.5 h,cellular polarity changed with the direction of the force.The c-fos mRNA was weak in RPE cells that were not exposed to shear stress.With exposure to 2 dyne/cm2 of shear stress,c-fos mRNA increased gradually,and reached a peak at 1.5 h,then subsequently decreased.When exposed to shear stress for 3 h,the c-fos mRNA in RPE cells was still higher than that of cells that were not exposed to stress.With treatment of 2 dyne/cm2 of shear stress,c-myc mRNA reached a peak at 1.5 h,and then slightly decreased.The expression of c-myc mRNA at 3 h was still higher than that in cells that were not treated with stress.Conclusion Shear stress of 2 dyne/cm2 can change the morphology of RPE cells,and quickly up-regulate c-fos and c-myc mRNA within a short period of time.Compared to c-myc,c-fos increases faster,and peaks at a higher level." @default.
- W2365054617 created "2016-06-24" @default.
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- W2365054617 date "2009-01-01" @default.
- W2365054617 modified "2023-09-27" @default.
- W2365054617 title "Effect of shear stress on the expression of c-fos and c-myc mRNA in cultured human retinal pigment epithelial cells" @default.
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