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- W2365064585 abstract "Objective To research the modle of HBVDNA mutation and the change of immune environment in the Chronic hepatitis B patients after Lamivudine resistance.Methods We analysised the HBVDNA P gene mutation of chronic hepatitis B after Lamivudine resistance use Polymerase chain reaction and gene Sequencing,compared the level of INF-γ、IL-2、IL-4 in the hepatitis B patient's serum whose HBVDNA mutated with control group on the sixth Treatment Month and after the mutation occurred.Results The main modle of HBVDNA mutation were the follows:the mutation on gene rtM204I account for 34.7%,rtL180M+rtM204V account for 30.56%,rtL180M+rtM204I account for16.67%,rtV173L+rtV180M+rtM204V account for 12.5%。There were no difference between the level of INF-γ、IL-2、IL-4 factors of the two groups on the sixth treatment month,the level of IL-2、IFN-γin mutation group were lower than the control group,the level of IL-4 was higher than the control group.Conclusion The modle of HBVDNA mutation were the mutation rtM204I and the combine variation on rtL180M、rtV173L 、rtM204V、rtM204I gene,the predominant immune environment in the Chronic hepatitis B patients after Lamivudine resistance would change from Th1 to Th2." @default.
- W2365064585 created "2016-06-24" @default.
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- W2365064585 date "2010-01-01" @default.
- W2365064585 modified "2023-09-23" @default.
- W2365064585 title "The Modle of HBVDNA Mutation and the Change of Immune Environment in the Chronic Hepatitis B Patients after Lamivudine Resistance" @default.
- W2365064585 hasPublicationYear "2010" @default.
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