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- W2365076327 abstract "Aim:To investigate whether β-elemene could enhance the effects of radiotherapy on human squamous cell carcinoma of tongue transplanted models in nude mice and the effects on apoptosis and leukophil.Methods:Squamous cell carcinoma of tongue Tca-8113 cells were implanted into nude mice to establish 40 animal models which were divided into 5 groups at random:the control group,β-elemene group,radiation group,β-elemene (1 h) plus radiation group,and β-elemene (2 h) plus radiation group. The duration for tumor growth,apoptosis rate,and sum of leukophil were observed.Results:None of the mice died during the experiment. Duration for tumor growth of all groups were(8.62±3.81),(15.13±6.60),(22.00±6.32),(29.00±5.68)and(40.00±4.41)d.Interaction between β-elemene and radiation in the β-elemene (1 h) plus radiation group:F=0.015,P=0.902.Interaction between β-elemene and radiation in the β-elemene (2 h) plus radiation group:F=9.002,P=0.006.Apoptosis rates of all groups were (5.00±2.05)%,(11.99±2.47)%,(19.88±2.83)%,(27.11±4.84)%,and (34.84±4.62)%.Interaction between β-elemene and radiation in the β-elemene (1 h) plus radiation group:F=0.012,P=0.915.Interaction between β-elemene and radiation in the β-elemene (2 h) plus radiation group:F=12.837,P=0.001.Conclusion:β-elemene combined with radiotherapy could enhance the efficacy of radiotherapy on human squamous cell carcinoma of tongue transplanted models. When β-elemene is administered before radiotherapy,it has an evident radiosensitivity effect. β-elemene combined with radiotherapy could evidently induce the apoptosis which may be the mechanisms of the radiosensitivity effect.β-elemene shows no obvious inhibitive effect on leukophil." @default.
- W2365076327 created "2016-06-24" @default.
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- W2365076327 date "2010-01-01" @default.
- W2365076327 modified "2023-09-24" @default.
- W2365076327 title "Effects of β-elemene combined with radiotherapy on human squamous cell carcinoma of tongue transplanted model in nude mice" @default.
- W2365076327 hasPublicationYear "2010" @default.
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