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- W2365101958 abstract "Objective To investigate the gene expression of glial cell derived neurotrophic factor(GDNF) in different segments of Hirschsprung′s disease(HD).Methods Forty-two pairs of full thickness specimens(aganglionic segments and ganglionic segments)from HD patients were collected from several hospitals soon after operation(33 boys,9 girls,aged from 2 months to 10 years).All the specimens were sporadic cases,and all the cases were proved by histopathologic diagnosis,including the common type 30 cases,short term type 12 cases.Another 5 colon specimens were obtained from intussusception patients as controls(4 boys,1 girl,aged from 30 days to 8 years).The GDNF mRNA expression in different parts of HD segments and non-HD segments were detected using semi-quantitative reverse transcriptase polymerase chain reaction(RT-PCR),then the relationships between their expression and the clinical features were analyzed.Results In normal controls,GDNF mRNA was positive in 5 out of 5(100%).Meanwhile,of all the 42 fresh samples of HD,GDNF mRNA was positive in 40(95.2%) in dilated segment.However,positive rate of GDNF mRNA was decreased to 15 in transitional zone(35.7%) and to 11 in spastic segment(26.2%).GDNF mRNA expression in the aganglionic segments were decreased,compared with the ganglionic segments and control group(P0.05).There were no statistical differences in GDNF mRNA expression between control group and the ganglionic segments group.Of all the aganglionic segments group,GDNF mRNA expression in short segment aganglionosis group was less than that in long segment-type HD group(P0.05).Conclusions The expression of GDNF mRNA is abnormal in aganglionic segments and migrate segments,and its expression may be related to the pathological types of HD.GDNF may play a certain role in the pathogenesis of HD." @default.
- W2365101958 created "2016-06-24" @default.
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- W2365101958 date "2008-01-01" @default.
- W2365101958 modified "2023-09-26" @default.
- W2365101958 title "Expression of Glial Cell Derived Neurotrophic Factor in Hirschsprung's Disease" @default.
- W2365101958 hasPublicationYear "2008" @default.
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