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- W2365104988 abstract "Aim To investigate the effects of Rb AS-ODN on apoptosis and drug sensitivity of osteosarcoma cell. Methods MG-63 cells were transfected with Rb AS-ODN by cationic liposome, S-ODN and LP in vitro.The expression of pRb treated with or without AS-ODN ,S-ODNand LP in MG-63 cells was observed by Western blot. The Flow cytometer(FCM) was used to examine apoptosis induced by ADM in MG-63 cells. The MTT assay was used to measure chemotherapeutic agent-sensitivity of MG-63 cells treated with ADM. Results The level of pRb expression in the MG-63 osteosarcoma line transfected with Rb AS-ODN obviously reduced compared with that of controls ,which were treated with S-ODN,LP and non-transfected(P0.05). The percentage of the apoptotic cells and drug-sensitivity of MG-63 cells treated with Rb AS-ODN and ADM decreased compared with that of the controls(P0.05). Conclusion The transfection of Rb AS-ODN delivered by cationic liposome could inhibit apoptosis induced with ADM in MG-63 cells and decrease drug-sensitivity of MG-63 cells to ADM." @default.
- W2365104988 created "2016-06-24" @default.
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- W2365104988 date "2004-01-01" @default.
- W2365104988 modified "2023-09-25" @default.
- W2365104988 title "The Effects of Rb AS-ODN on Apoptosis and Drug Sensitivity of Osteogeinc Sarcoma" @default.
- W2365104988 hasPublicationYear "2004" @default.
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