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- W2365115964 abstract "AIM To investigate the effects of recombinant human brain natriuretic peptide(rhBNP) on endothelial function and left ventricular diastolic function in patients with initialonset of diastolic heart failure(DHF).METHODS Sixty-five patients with initialonset of DHF were randomly divided into two groups.Control group(30 patients) was treated with the routine anti-heart failure therapy,while rhBNP group(35 patients) was assigned under the routine therapy plus rhBNP(1.5 μg·kg-1 intravenous bolus followed by a 0.007 5 μg· kg -1·min -1 infusion for 5 hours,once a week for 12 weeks).Before and after 12 weeks' treatment,left ventricular diastolic function,endothelin-1(ET-1),nitric oxide(NO) and von willebrand factor(vWF) were measured respectively for both groups.RESULTS After treatment,E / A and serum NO in the rhBNP group were significantly higher than that in the control group((1.1 ± s 0.4) vs(0.8 ± 0.5),(67 ± 13) μmol·L-1 vs(49 ± 13) μmol·L-1),respectively(P 0.05);isovolumicetric relaxation time(IVRT),E-wave deceleration time(EDT),systolic blood pressure,ET-1,vWF were lower than those in the control group((80 ± 6) ms vs(95 ± 6) ms,(140 ± 21) ms vs(161 ± 28) ms,(141 ± 23) mmHg vs(146 ± 30) mmHg,(43 ± 28) ng· L-1 vs(56 ± 12) ng·L-1,(110 ± 24) % vs(149 ± 32) %),respectively(P 0.05).CONCLUSION rhBNP can protect endothelial function,improve left ventricular diastolic function and reduce blood pressure for initialonset DHF." @default.
- W2365115964 created "2016-06-24" @default.
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- W2365115964 date "2009-01-01" @default.
- W2365115964 modified "2023-09-22" @default.
- W2365115964 title "Effects of recombinant human brain natriuretic peptide on endothelial function and left ventricular diastolic function in diastolic heart failure" @default.
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