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- W2365122693 abstract "Objective To investigate the effects of laminaria japonica(L.japonica)on serum lipid of experimental hyperlipemia in rats.Methods Forty healthy female Wistar rats were involved in this study,and 10 were selected from among them in random assigned as normal controls to be fed with ordinary forage,and the rest 30 were offered high-fat diet to create a hyperlipemia(HL)model in rats.After four weeks of feeding,24 rats with HL were equally randomized to model-control group,Sim-vastatin group and L.japonica group.For model-control group,ordinary forage was continued;for Simvastatin group,the drug was given intragastrically,10 mg/kg diluted in 1ml normal saline,once a day;for those in L.japonica group,the diet mixed with L.japonica powder was supplied,the course was two weeks for all the three groups.The serum triglyceride(TG),total cholesterol(TC),low-density lipoprotein(LDL),high-density lipoprotein(HDL),malondialdehyde(MDA),nitric oxide(NO)and the activity of superoxide dismutase(SOD),glutathione peroxidase(GSH-PX),lipoprotein lipase(LPL)and hepatic lipase(HL)were measured.Results The serum TG,TC and LDL in both Simvastatin and L.japonica groups were lower than that in the control,while the serum HDL elevated(F=4.22-37.04,q=4.76-13.57,P0.05),but no significant differences of that were found between Simvastatin group and L.japonica group(q=0.31-3.15,P0.05).The serum LPL and HL of rats in Simvastatin group and L.japonica group were markedly higher than those in the normal control and model-control group(F=68.79,92.12;q=5.51-19.09;P0.05).The serum MDA and NO in Simvastatin group and L.japonica group were significantly lower than that of the model-control(F=8.24,39.01;q=4.66-14.32;P0.05),while the activity of serum SOD and GSH-PX was significantly higher(F=21.23,31.61;q=9.20-11.21;P0.05).A comparison between Simvastatin and L.japonica groups showed no significant differences in MDA,NO,SOD and GSH-PX were noticed(q=0.95-2.69,P0.05).Conclusion L.japonica may have an effect similar to Simvastatins,which affects the metabolism of TG,TC,LDL and HDL to educe a regulation of blood lipid by enhancing the activity of LPL and HL." @default.
- W2365122693 created "2016-06-24" @default.
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- W2365122693 date "2010-01-01" @default.
- W2365122693 modified "2023-09-25" @default.
- W2365122693 title "EFFECTS OF LAMINARIA JAPONICA ON SERUM LIPID IN RATS WITH EXPERIMENTAL HYPERLIPEMIA" @default.
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