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- W2365132485 abstract "Objective To study the expression and clinical significant of DNA of p53,p16 tumor suppressor gene and infection of bacteria L-forms in ovarian tumors.Methods Nucleic acid hybridization in situ was used to examine the positive signal of p53,p16 tumor suppressor gene and bacteria L-forms in 101 cases of ovarian tumors.Results The positive signal of p53 mRNA was significantly higher in malignant tumor than that in benign tumor(P0.01).The positive signal of p16 mRNA was lower in malignant tumor than that in benign tumor(P0.01).The index of the two tumor suppressor gene has obvious relationship with grade and prognosis for patients(P(0.05)).The positive signal of bacteria L-forms has significant difference with grade,and the positive signal in patients with celiac lymph node metastasis and ascites was significant higher than in that without the metastasis and ascites(P0.05).Conclusion p53 mRNA has certain abnormal expression in ovarian neoplasms.The expression of p16 mRNA is in negative correlation with cell differentiation.Both of the two genes could be useful markers of biological behavior of tumors and prognosis for patients.Infection of bacteria L-forms is probably one of the inductive factors of the occurrence of tumor,and perhaps has the function of positive cooperativity during the course.To study the relationship between tumor and bacteria L-forms was valuable for clinical practice." @default.
- W2365132485 created "2016-06-24" @default.
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- W2365132485 date "2005-01-01" @default.
- W2365132485 modified "2023-09-27" @default.
- W2365132485 title "Expression and the significance of DNA of p53、p16 tumor suppressor gene and bacterial L-forms in ovarian tumors" @default.
- W2365132485 hasPublicationYear "2005" @default.
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