Matches in SemOpenAlex for { <https://semopenalex.org/work/W2365137029> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W2365137029 endingPage "24" @default.
- W2365137029 startingPage "21" @default.
- W2365137029 abstract "Objective To study the effects of acitretin on the expression of signaling pathway- related genes in an epidermal squamous-cell carcinoma cell line. Methods The mRNA expression levels of STAT3, cyclin D1 and p42/44MAPK were detected in a human epidermal carcinoma cell line A431 by RT- PCR, Their expressions at protein level were studied by Western blot, The expression levels were studied in cells treated with or without 10-5 mol/L acitretin at different time intervals. Results （ 1 ） Acitretin could significantly inhibit the expression of STAT3 and cyclin D1 mRNA in a time-dependent manner （ P 〈 0.05 ）. The STAT3 and cyclin D1 protein expression levels were down-regulated. Acitretin could also down-regulate the p42/4MAPK mRNA expression. （2）After incubation with acitretin, the mRNA level of cyclin D1 cells was positively correlated with that of STAT3 （ P 〈 0.05 ）. The cyclin D1 protein level was also positively correlated with that of STAT3 （ P 〈 0.05 ）. However there was no correlation of mRNA levels between cyclin D1 and p42/44MAPK. Conclusion Regulation of the Jak/STAT3 signaling pathway may play an important role in the effect of acitretin on epidermal squamous-cell carcinoma cells. The abnormal expression of STAT3 can be regarded as a prerequisite for acitretin treatment effect.Key words: Acitretin ; Signaling pathway ; Genes expression" @default.
- W2365137029 created "2016-06-24" @default.
- W2365137029 creator A5045796734 @default.
- W2365137029 creator A5052135528 @default.
- W2365137029 creator A5081325802 @default.
- W2365137029 date "2006-01-01" @default.
- W2365137029 modified "2023-09-23" @default.
- W2365137029 title "[Effects of acitretin on the expression of signaling pathway-related genes in epidermal squamous-cell carcinoma cells]." @default.
- W2365137029 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16737614" @default.
- W2365137029 hasPublicationYear "2006" @default.
- W2365137029 type Work @default.
- W2365137029 sameAs 2365137029 @default.
- W2365137029 citedByCount "0" @default.
- W2365137029 crossrefType "journal-article" @default.
- W2365137029 hasAuthorship W2365137029A5045796734 @default.
- W2365137029 hasAuthorship W2365137029A5052135528 @default.
- W2365137029 hasAuthorship W2365137029A5081325802 @default.
- W2365137029 hasConcept C11882975 @default.
- W2365137029 hasConcept C1491633281 @default.
- W2365137029 hasConcept C153911025 @default.
- W2365137029 hasConcept C199835354 @default.
- W2365137029 hasConcept C203014093 @default.
- W2365137029 hasConcept C2778496887 @default.
- W2365137029 hasConcept C2780564577 @default.
- W2365137029 hasConcept C29537977 @default.
- W2365137029 hasConcept C502942594 @default.
- W2365137029 hasConcept C55493867 @default.
- W2365137029 hasConcept C62478195 @default.
- W2365137029 hasConcept C86803240 @default.
- W2365137029 hasConcept C95444343 @default.
- W2365137029 hasConceptScore W2365137029C11882975 @default.
- W2365137029 hasConceptScore W2365137029C1491633281 @default.
- W2365137029 hasConceptScore W2365137029C153911025 @default.
- W2365137029 hasConceptScore W2365137029C199835354 @default.
- W2365137029 hasConceptScore W2365137029C203014093 @default.
- W2365137029 hasConceptScore W2365137029C2778496887 @default.
- W2365137029 hasConceptScore W2365137029C2780564577 @default.
- W2365137029 hasConceptScore W2365137029C29537977 @default.
- W2365137029 hasConceptScore W2365137029C502942594 @default.
- W2365137029 hasConceptScore W2365137029C55493867 @default.
- W2365137029 hasConceptScore W2365137029C62478195 @default.
- W2365137029 hasConceptScore W2365137029C86803240 @default.
- W2365137029 hasConceptScore W2365137029C95444343 @default.
- W2365137029 hasIssue "1" @default.
- W2365137029 hasLocation W23651370291 @default.
- W2365137029 hasLocation W23651370292 @default.
- W2365137029 hasOpenAccess W2365137029 @default.
- W2365137029 hasPrimaryLocation W23651370291 @default.
- W2365137029 hasRelatedWork W1944738757 @default.
- W2365137029 hasRelatedWork W1946894092 @default.
- W2365137029 hasRelatedWork W1985157891 @default.
- W2365137029 hasRelatedWork W2015215437 @default.
- W2365137029 hasRelatedWork W2039310084 @default.
- W2365137029 hasRelatedWork W2104048832 @default.
- W2365137029 hasRelatedWork W2148574613 @default.
- W2365137029 hasRelatedWork W2150583853 @default.
- W2365137029 hasRelatedWork W2355891971 @default.
- W2365137029 hasRelatedWork W2363240681 @default.
- W2365137029 hasRelatedWork W2379128030 @default.
- W2365137029 hasRelatedWork W2390597801 @default.
- W2365137029 hasRelatedWork W2473166065 @default.
- W2365137029 hasRelatedWork W2566702584 @default.
- W2365137029 hasRelatedWork W2752159881 @default.
- W2365137029 hasRelatedWork W2795101768 @default.
- W2365137029 hasRelatedWork W2810911716 @default.
- W2365137029 hasRelatedWork W3028791605 @default.
- W2365137029 hasRelatedWork W3032573201 @default.
- W2365137029 hasRelatedWork W3140569507 @default.
- W2365137029 hasVolume "28" @default.
- W2365137029 isParatext "false" @default.
- W2365137029 isRetracted "false" @default.
- W2365137029 magId "2365137029" @default.
- W2365137029 workType "article" @default.