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- W2365139921 abstract "Objective To compare the in vitro transdermal penetration of ketoprofen ethosomal(KPFE) gels and liposomal(KPFL) gels to screen the optimal external preparation for KPF.Methods KPFE gels and KPFL gels were prepared.Skipped mouse skin as the barrier,the in vitro transdermal penetration of the two gels was studied and compared by using Franz diffusion cells.Results Both the in vitro transdermal penetration of the two gels was fitted with Higuchi equation,Q=28.65 t1/2-16.88(R2=0.995) for KPFL gels and Q=35.22 t1/2-20.62(R2=0.988) for KPFE gels.The stability penetration rate was 28.65 μg·cm-2·h-1 and 35.22 μg·cm-2·h-1,respectively.After 24 h transdermal penetration,the KPF cumulative amount in skin and residual amount in the gels was 22.16 μg·cm-2 and 19.95 μg·cm-2,56.25 μg·cm-2 and 50.62 μg·cm-2,respectively.The above indices all showed significant difference between the two gels.Conclusion Compared with KPFL gels,KPFE gels exhibited better transdermal enhancement in the transdermal drug delivery systems." @default.
- W2365139921 created "2016-06-24" @default.
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- W2365139921 date "2012-01-01" @default.
- W2365139921 modified "2023-10-11" @default.
- W2365139921 title "Comparative study on in vitro transdermal penetration of ketoprofen ethosomal gels and liposomal gels" @default.
- W2365139921 hasPublicationYear "2012" @default.
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