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- W2365144895 abstract "Aim:To investigate the effects of 5-FU and VM-26 on the proliferation and apoptosis of gastric cancer cell line BGC-823.Methods:MTT assay was used to examine the inhibition rate of cell growth when BGC-823 cells were treated with various concentrations of 5-FU(15.63,31.25,62.50,125.00,250.00 mg/L),VM-26(1.25,2.50,5.00,10.00,20.00 mg/L) single and combination for 48 h;the distribution of cell cycle phases and the apoptosis rate were examined by flow cytometry.Results: The inhibition rate of cell growth was enhanced in a dose-depandent manner when BGC-823 cells were treated with various concentrations 5-FU,VM-26 single or combined.When BGC-823 cells were treated with 1.25 mg/L VM-26,the cell cycle was arrested in the G2/M phase at 48 h.When BGC-823 cells were treated with 15.63 mg/L 5-FU,the cell cycle was arrested in the S phase at 12,24 h. When 1.25 mg/L VM-26 was combined with 15.63 mg/L 5-FU,the distribution of the cell cycle phase was different from that of single drug.The apoptosis rate in joint drug group at 12,24 h was higher than that in single drug group.Conclusion:5-FU and VM-26 single can inhibit the growth of BGC-823.The inhibition rate of the low-dose joint group is higher than the single drug.5-FU and VM-26 single and combination both can induce apoptosis,but induce different cell cycle phase distribution." @default.
- W2365144895 created "2016-06-24" @default.
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- W2365144895 date "2009-01-01" @default.
- W2365144895 modified "2023-09-24" @default.
- W2365144895 title "Effects of 5-FU and VM-26 on proliferation and apoptosis of gastric cancer cell line BGC-823" @default.
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